Nanotheranostics of Pre‐Stenotic Vessels By Target Touch‐On Signaling of Peptide Navigator

Navigation of nanoparticles to target sites blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment pre-stenotic vessels can prevent irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using navigation function subsequent binding-on signaling P. as a game-changer. When rabbit allografted with injecting contrast-loaded liposomes, case-dependent stenotic degree after 2–6 weeks be diagnosed accurately within 2–4 days via computed tomography imaging cross-validation mouse model partial carotid ligation. Furthermore, anti-CDK9 NV is activated post-targeting effectively prevents stenosis suppressing inflammation lipotoxicity vessels, serum, and/or liver. CDK9 targeting confirmed computer, vitro, vivo models. This study demonstrates an unprecedented for future clinical applications.